|Title||Immunologically relevant effects of radiation therapy on the tumor microenvironment.|
|Publication Type||Journal Article|
|Year of Publication||2023|
|Authors||Galassi C, Klapp V, Formenti SC, Demaria S, Galluzzi L|
|Date Published||2023 May 18|
Focal radiation therapy (RT) has been successfully employed to clinically manage multiple types of cancer for more than a century. Besides being preferentially cytotoxic for malignant cells over their nontransformed counterparts, RT elicits numerous microenvironmental alterations that appear to factor into its therapeutic efficacy. Here, we briefly discuss immunostimulatory and immunosuppressive microenvironmental changes elicited by RT and their impact on tumor recognition by the host immune system.
|Alternate Journal||Essays Biochem|
|Grant List||U54 CA274291 / CA / NCI NIH HHS / United States|
Sandra Demaria, M.D.