How do viruses trick B cells into becoming lymphomas?

TitleHow do viruses trick B cells into becoming lymphomas?
Publication TypeJournal Article
Year of Publication2014
AuthorsCesarman E
JournalCurr Opin Hematol
Volume21
Issue4
Pagination358-68
Date Published2014 Jul
ISSN1531-7048
KeywordsCell Transformation, Viral, Humans, Lymphoma
Abstract

PURPOSE OF REVIEW: Since the discovery of Epstein-Barr virus in Burkitt's lymphoma 50  years ago, only one other virus, namely Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8, has been confirmed to be a direct cause of B-cell lymphoma. Here we will review the evidence for Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus as causal lymphoma agents.

RECENT FINDINGS: A deeper understanding of specific mechanisms by which Epstein-Barr virus and Kaposi's sarcoma-associated herpesvirus cause B-cell lymphomas has been acquired over the past years, in particular with respect to viral protein interactions with host cell pathways, and microRNA functions. Specific therapies based on knowledge of viral functions are beginning to be evaluated, mostly in preclinical models.

SUMMARY: Understanding the causal associations of specific infectious agents with certain B-cell lymphomas has allowed more accurate diagnosis and classification. A deeper knowledge of the specific mechanisms of transformation is essential to begin assessing whether virus-targeted treatment modalities may be used in the future.

DOI10.1097/MOH.0000000000000060
Alternate JournalCurr Opin Hematol
PubMed ID24886824
Grant ListR21EB016803 / EB / NIBIB NIH HHS / United States
R01-CA103646 / CA / NCI NIH HHS / United States
R01-CA154228 / CA / NCI NIH HHS / United States
3P30CA008748 / CA / NCI NIH HHS / United States
U01CA-121947 / CA / NCI NIH HHS / United States
Related Faculty: 
Ethel Cesarman, M.D., Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
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