| Title | Histiocytic Sarcoma Following B-Lymphoblastic Leukemia/Lymphoma. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Geyer JT, Yigit N, Miyaguchi A, Cheng S, Casano J, Mathew S, Desai P, Gergis U, Tam W |
| Journal | Am J Clin Pathol |
| Volume | 152 |
| Issue | 4 |
| Pagination | 486-494 |
| Date Published | 2019 09 09 |
| ISSN | 1943-7722 |
| Keywords | Breast Neoplasms, Female, Gene Rearrangement, High-Throughput Nucleotide Sequencing, Histiocytic Sarcoma, Humans, Middle Aged, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Proto-Oncogene Proteins c-myc |
| Abstract | OBJECTIVES: Rare cases of clonally related histiocytic sarcoma (HS) following B-lymphoblastic leukemia/lymphoma (B-ALL/LBL) have been reported to date. METHODS: We present a patient with HS, which appeared as a breast mass 12 months after the initial diagnosis of B-ALL. RESULTS: Both HS and the B-ALL shared IGH-MYC and IGK gene rearrangements. Next-generation sequencing and whole-exome sequencing (WES) studies detected 35 common mutations, as well as mutations unique to B-ALL (16) and HS (15), including BRAF D594G. The patient achieved complete remission of B-ALL, but HS failed to respond to many cycles of intensive chemotherapy regimens. A partial response was achieved with sorafenib, a BRAF-targeted therapy. CONCLUSIONS: To our knowledge, this is the first study to demonstrate by WES that clonally related B-ALL and HS arise through divergent evolution from a common precursor. We present our findings together with a discussion of the previously reported cases of HS in patients with B-ALL. |
| DOI | 10.1093/ajcp/aqz056 |
| Alternate Journal | Am J Clin Pathol |
| PubMed ID | 31172191 |
Related Faculty:
Julia Geyer, M.D.