| Title | High dose intravenous methotrexate with leucovorin rescue in rheumatoid arthritis. |
| Publication Type | Journal Article |
| Year of Publication | 1988 |
| Authors | Shiroky J, Allegra C, Inghirami G, Chabner B, Yarboro C, Klippel JH |
| Journal | J Rheumatol |
| Volume | 15 |
| Issue | 2 |
| Pagination | 251-5 |
| Date Published | 1988 Feb |
| ISSN | 0315-162X |
| Keywords | Arthritis, Rheumatoid, Drug Therapy, Combination, HLA-DR Antigens, Humans, Injections, Intravenous, Leucovorin, Methotrexate, Pain, Pilot Projects, Recurrence, T-Lymphocytes |
| Abstract | Five patients with severe, treatment refractory rheumatoid arthritis were treated with high dose intravenous methotrexate (500 mg/m2) followed by leucovorin (50 mg/m2). Four courses of chemotherapy were given over a 2-month interval. At the end of the final course, there was a 50% or greater improvement in joint swelling and pain indices and morning stiffness in all patients. Clinical responses persisted for 6-14 weeks posttherapy. High dose methotrexate-leucovorin was associated with a significant reduction in DR antigen expression on peripheral Leu 2, Leu 3 and Leu 4 lymphocytes. |
| Alternate Journal | J Rheumatol |
| PubMed ID | 3258915 |
Related Faculty:
Giorgio Inghirami, M.D.