|Title||High dose intravenous methotrexate with leucovorin rescue in rheumatoid arthritis.|
|Publication Type||Journal Article|
|Year of Publication||1988|
|Authors||Shiroky J, Allegra C, Inghirami G, Chabner B, Yarboro C, Klippel JH|
|Date Published||1988 Feb|
|Keywords||Arthritis, Rheumatoid, Drug Therapy, Combination, HLA-DR Antigens, Humans, Injections, Intravenous, Leucovorin, Methotrexate, Pain, Pilot Projects, Recurrence, T-Lymphocytes|
Five patients with severe, treatment refractory rheumatoid arthritis were treated with high dose intravenous methotrexate (500 mg/m2) followed by leucovorin (50 mg/m2). Four courses of chemotherapy were given over a 2-month interval. At the end of the final course, there was a 50% or greater improvement in joint swelling and pain indices and morning stiffness in all patients. Clinical responses persisted for 6-14 weeks posttherapy. High dose methotrexate-leucovorin was associated with a significant reduction in DR antigen expression on peripheral Leu 2, Leu 3 and Leu 4 lymphocytes.
|Alternate Journal||J Rheumatol|
Giorgio Inghirami, M.D.