Herpesvirus 8 inclusions in primary effusion lymphoma: report of a unique case with T-cell phenotype.

TitleHerpesvirus 8 inclusions in primary effusion lymphoma: report of a unique case with T-cell phenotype.
Publication TypeJournal Article
Year of Publication1999
AuthorsSaid JW, Shintaku IP, Asou H, deVos S, Baker J, Hanson G, Cesarman E, Nador R, Koeffler HP
JournalArch Pathol Lab Med
Volume123
Issue3
Pagination257-60
Date Published1999 Mar
ISSN0003-9985
KeywordsAdult, Herpesviridae Infections, Herpesvirus 8, Human, Humans, Immunohistochemistry, Immunophenotyping, In Situ Hybridization, Lymphoma, Male, Pleural Effusion, Malignant, T-Lymphocytes
Abstract

We describe a case of primary effusion lymphoma with T-cell phenotype, mixed genotype, and intranuclear herpesvirus inclusions visible with the light microscope. Cells were studied by immunohistochemical analysis, in situ hybridization, immunoglobulin and T-cell receptor gene rearrangement, and polymerase chain reaction. Primary effusion lymphoma cells with T-cell phenotype revealed herpesvirus 8 inclusions predominantly seen in apoptotic cells, suggesting that productive viral infection is associated with cell death. Clinical features were typical of primary effusion lymphoma. Cytologic, molecular genetic, and phenotypic features demonstrated a unique variant of primary effusion lymphoma.

DOI10.5858/1999-123-0257-HIIPEL
Alternate JournalArch Pathol Lab Med
PubMed ID10086517
Grant ListR0173533 / / PHS HHS / United States
UO1 CA 66533-02 / CA / NCI NIH HHS / United States
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