| Title | The genetic landscape of mutations in Burkitt lymphoma. |
| Publication Type | Journal Article |
| Year of Publication | 2012 |
| Authors | Love C, Sun Z, Jima D, Li G, Zhang J, Miles R, Richards KL, Dunphy CH, Choi WWL, Srivastava G, Lugar PL, Rizzieri DA, Lagoo AS, Bernal-Mizrachi L, Mann KP, Flowers CR, Naresh KN, Evens AM, Chadburn A, Gordon LI, Czader MB, Gill JI, Hsi ED, Greenough A, Moffitt AB, McKinney M, Banerjee A, Grubor V, Levy S, Dunson DB, Dave SS |
| Journal | Nat Genet |
| Volume | 44 |
| Issue | 12 |
| Pagination | 1321-5 |
| Date Published | 2012 Dec |
| ISSN | 1546-1718 |
| Keywords | Ammonia-Lyases, Base Sequence, Burkitt Lymphoma, Cell Line, Tumor, Chaperonin Containing TCP-1, DNA Helicases, DNA-Binding Proteins, Genes, myc, Genome, Human, Glutamate Formimidoyltransferase, GTP-Binding Protein alpha Subunits, G12-G13, Homeodomain Proteins, Humans, Inhibitor of Differentiation Proteins, Intracellular Signaling Peptides and Proteins, Lymphoma, Large B-Cell, Diffuse, Membrane Proteins, Molecular Sequence Data, Multifunctional Enzymes, Mutation, Neoplasm Proteins, Nuclear Proteins, Proto-Oncogene Proteins c-ret, Sequence Analysis, DNA, Transcription Factors, Translocation, Genetic |
| Abstract | Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the same affected individual. We further sequenced the exomes of 59 Burkitt lymphoma tumors and compared them to sequenced exomes from 94 diffuse large B-cell lymphoma (DLBCL) tumors. We identified 70 genes that were recurrently mutated in Burkitt lymphomas, including ID3, GNA13, RET, PIK3R1 and the SWI/SNF genes ARID1A and SMARCA4. Our data implicate a number of genes in cancer for the first time, including CCT6B, SALL3, FTCD and PC. ID3 mutations occurred in 34% of Burkitt lymphomas and not in DLBCLs. We show experimentally that ID3 mutations promote cell cycle progression and proliferation. Our work thus elucidates commonly occurring gene-coding mutations in Burkitt lymphoma and implicates ID3 as a new tumor suppressor gene. |
| DOI | 10.1038/ng.2468 |
| Alternate Journal | Nat Genet |
| PubMed ID | 23143597 |
| PubMed Central ID | PMC3674561 |
| Grant List | T32 GM007184 / GM / NIGMS NIH HHS / United States R21CA1561686 / CA / NCI NIH HHS / United States R01 CA136895 / CA / NCI NIH HHS / United States R01 ES017436 / ES / NIEHS NIH HHS / United States R01CA136895 / CA / NCI NIH HHS / United States |
Related Faculty:
Amy Chadburn, M.D.