| Title | Functional regulation of FoxO1 in neural stem cell differentiation. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Kim D-Y, Hwang I, Muller FL, Paik J-H |
| Journal | Cell Death Differ |
| Volume | 22 |
| Issue | 12 |
| Pagination | 2034-45 |
| Date Published | 2015 Dec |
| ISSN | 1476-5403 |
| Keywords | 3' Untranslated Regions, Animals, Base Sequence, Cell Differentiation, Cells, Cultured, Forkhead Box Protein O1, Forkhead Transcription Factors, Mice, MicroRNAs, Microtubule-Associated Proteins, Nestin, Neural Stem Cells, Neuropeptides, Receptors, Notch, Sequence Alignment, Signal Transduction, Tubulin |
| Abstract | Forkhead transcription factor family O (FoxO) maintains adult stem cell reserves by supporting their long-term proliferative potential. MicroRNAs (miRs) regulate neuronal stem/progenitor cell (NSPC) proliferation and differentiation during neural development by controlling the expression of a specific set of target genes. In the neurogenic subventricular zone, FoxO1 is specifically expressed in NSPCs and is no longer detected during the transition to neuroblast stage, forming an inverse correlation with miR-9 expression. The 3'-untranslated region of FoxO1 contains a conserved target sequence of miR-9 and FoxO1 expression is coordinated in concert with miR-9 during neuronal differentiation. Our study demonstrates that FoxO1 contributes to NSPC fate decision through its cooperation with the Notch signaling pathway. |
| DOI | 10.1038/cdd.2015.123 |
| Alternate Journal | Cell Death Differ |
| PubMed ID | 26470727 |
| PubMed Central ID | PMC4816100 |
| Grant List | R01 AG048284 / AG / NIA NIH HHS / United States AG048284 / AG / NIA NIH HHS / United States |
Related Lab:
Related Faculty:
Ji-Hye Paik, Ph.D.