Functional regulation of FoxO1 in neural stem cell differentiation.

TitleFunctional regulation of FoxO1 in neural stem cell differentiation.
Publication TypeJournal Article
Year of Publication2015
AuthorsKim D-Y, Hwang I, Muller FL, Paik J-H
JournalCell Death Differ
Date Published2015 Dec
Keywords3' Untranslated Regions, Animals, Base Sequence, Cell Differentiation, Cells, Cultured, Forkhead Box Protein O1, Forkhead Transcription Factors, Mice, MicroRNAs, Microtubule-Associated Proteins, Nestin, Neural Stem Cells, Neuropeptides, Receptors, Notch, Sequence Alignment, Signal Transduction, Tubulin

Forkhead transcription factor family O (FoxO) maintains adult stem cell reserves by supporting their long-term proliferative potential. MicroRNAs (miRs) regulate neuronal stem/progenitor cell (NSPC) proliferation and differentiation during neural development by controlling the expression of a specific set of target genes. In the neurogenic subventricular zone, FoxO1 is specifically expressed in NSPCs and is no longer detected during the transition to neuroblast stage, forming an inverse correlation with miR-9 expression. The 3'-untranslated region of FoxO1 contains a conserved target sequence of miR-9 and FoxO1 expression is coordinated in concert with miR-9 during neuronal differentiation. Our study demonstrates that FoxO1 contributes to NSPC fate decision through its cooperation with the Notch signaling pathway.

Alternate JournalCell Death Differ
PubMed ID26470727
PubMed Central IDPMC4816100
Grant ListR01 AG048284 / AG / NIA NIH HHS / United States
AG048284 / AG / NIA NIH HHS / United States
Related Faculty: 
Ji-Hye Paik, Ph.D.

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