|Title||Follicular Dendritic Cell Sarcoma of Uterine Corpus: Report of 2 Cases.|
|Publication Type||Journal Article|
|Year of Publication||2023|
|Authors||Boyraz B, Post MD, Hasserjian RP, Oliva E|
|Journal||Int J Gynecol Pathol|
|Date Published||2023 Jul 01|
|Keywords||Biomarkers, Tumor, Biopsy, Dendritic Cell Sarcoma, Follicular, Endometrium, Female, Humans, Hysterectomy, Uterus|
Follicular dendritic cell sarcoma is a rare dendritic/histiocytic tumor of intermediate malignant potential, which often involves extranodal sites, most commonly the gastrointestinal tract and mediastinum with only 5 cases reported in the female genital tract. We present the clinical and pathologic features of 2 such examples arising in the uterine corpus. Both patients (63 and 72-yr old) presented with postmenopausal bleeding and underwent an endometrial biopsy diagnostic of follicular dendritic cell sarcoma that was followed by hysterectomy. The tumors were polypoid, 3.5 and 5.0 cm, and were confined to the endometrium. Microscopically, ovoid to round to spindled tumor cells with pale eosinophilic cytoplasm and vesicular nuclei were arranged predominantly in sheets with an accompanying lymphocyte-rich inflammatory infiltrate. The tumor cells were positive for CD35, CD23, D2-40 in both tumors and additionally positive for CD21 in 1 tumor, all highlighting cell bodies and processes. Patients were alive without evidence of disease at 1 and 4 years with no adjuvant treatment. These cases highlight the importance of entertaining a broad differential diagnosis in lesions with epithelioid and/or spindled morphology involving the uterus.
|Alternate Journal||Int J Gynecol Pathol|
Baris Boyraz, M.D., Ph.D.