|Title||The fluidity of liver plasma membranes from patients with different types of liver injury.|
|Publication Type||Journal Article|
|Year of Publication||1986|
|Authors||Schüller A, Solis-Herruzo JA, Moscat J, Fernandez-Checa JC, Municio AM|
|Date Published||1986 Jul-Aug|
|Keywords||5'-Nucleotidase, Adult, Aged, Cell Membrane, Female, Fluorescence Polarization, Humans, Liver Diseases, Male, Membrane Fluidity, Membrane Lipids, Membrane Proteins, Microscopy, Electron, Microscopy, Phase-Contrast, Middle Aged, Nucleotidases|
The physical properties of cell membranes play an important role in cellular homeostasis. Previous studies with animal models have shown that the hepatocyte membrane fluidity has important effects in cellular function. In order to further investigate the relationship between physical properties of membranes and liver disease, the present study was performed. Twenty-nine patients with different degrees of liver injury and 10 control individuals were studied. A lower membrane fluidity--as assessed by diphenylhexatriene fluorescence polarization--was observed in membrane preparations from patients, as compared to controls. These alterations are positively correlated with the severity of liver damage and could be accounted for by a higher cholesterol content of patients' membrane preparations.
Jorge Moscat, Ph.D.