The fluidity of liver plasma membranes from patients with different types of liver injury.

TitleThe fluidity of liver plasma membranes from patients with different types of liver injury.
Publication TypeJournal Article
Year of Publication1986
AuthorsSchüller A, Solis-Herruzo JA, Moscat J, Fernandez-Checa JC, Municio AM
JournalHepatology
Volume6
Issue4
Pagination714-7
Date Published1986 Jul-Aug
ISSN0270-9139
Keywords5'-Nucleotidase, Adult, Aged, Cell Membrane, Female, Fluorescence Polarization, Humans, Liver Diseases, Male, Membrane Fluidity, Membrane Lipids, Membrane Proteins, Microscopy, Electron, Microscopy, Phase-Contrast, Middle Aged, Nucleotidases
Abstract

The physical properties of cell membranes play an important role in cellular homeostasis. Previous studies with animal models have shown that the hepatocyte membrane fluidity has important effects in cellular function. In order to further investigate the relationship between physical properties of membranes and liver disease, the present study was performed. Twenty-nine patients with different degrees of liver injury and 10 control individuals were studied. A lower membrane fluidity--as assessed by diphenylhexatriene fluorescence polarization--was observed in membrane preparations from patients, as compared to controls. These alterations are positively correlated with the severity of liver damage and could be accounted for by a higher cholesterol content of patients' membrane preparations.

DOI10.1002/hep.1840060429
Alternate JournalHepatology
PubMed ID3015760
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