| Title | First Report of - and -Coharboring Species Isolated from a Pediatric Patient. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Chavda KD, Westblade LF, Satlin MJ, Hemmert AC, Castanheira M, Jenkins SG, Chen L, Kreiswirth BN |
| Journal | mSphere |
| Volume | 4 |
| Issue | 5 |
| Date Published | 2019 09 11 |
| ISSN | 2379-5042 |
| Keywords | beta-Lactamases, Child, Preschool, Egypt, Enterobacter, Enterobacteriaceae Infections, Genome, Bacterial, Humans, Male, Plasmids, Sequence Analysis, DNA, Travel-Related Illness, United States |
| Abstract | An isolate harboring and was recovered from a pediatric patient in a U.S. hospital. The and genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The gene is located between two insertion elements, IS and IS, but lacks the downstream regulatory genes ( and ) found in other isolates that harbor We describe the complete genome assembly and sequence of a clinical isolate harboring both and recovered from a pediatric patient in the United States with a history of travel to Egypt. Moreover, to the best of our knowledge, this is the first report of an isolate harboring both and from the United States. The and genes are carried on the same IncH12 plasmid, pME-1a. The isolate tested susceptible to colistin, without observed induction of colistin resistance. The gene is located between two insertion elements, IS and IS, but lacks the downstream regulatory genes ( and ) found in other isolates that harbor . |
| DOI | 10.1128/mSphere.00629-19 |
| Alternate Journal | mSphere |
| PubMed ID | 31511372 |
| PubMed Central ID | PMC6739498 |
| Grant List | R01 AI090155 / AI / NIAID NIH HHS / United States R21 AI135250 / AI / NIAID NIH HHS / United States |
Related Faculty:
Lars Westblade, Ph.D.