| Title | Feedback on fat: p62-mTORC1-autophagy connections. |
| Publication Type | Journal Article |
| Year of Publication | 2011 |
| Authors | Moscat J, Diaz-Meco MT |
| Journal | Cell |
| Volume | 147 |
| Issue | 4 |
| Pagination | 724-7 |
| Date Published | 2011 Nov 11 |
| ISSN | 1097-4172 |
| Keywords | Adaptor Proteins, Signal Transducing, Adipogenesis, Animals, Autophagy, Homeostasis, Humans, Inflammation, Metabolic Diseases, Mice, Multiprotein Complexes, Transcription Factors |
| Abstract | Metabolic homeostasis requires integration of multiple signals and cellular activities. Without this integration, conditions of obesity and diabetes often develop. Recent in vivo studies explore the molecular basis for metabolic homestasis, showing that p62 links autophagy and mTORC1 activation to regulate adipogenesis and energy control. |
| DOI | 10.1016/j.cell.2011.10.021 |
| Alternate Journal | Cell |
| PubMed ID | 22078874 |
| PubMed Central ID | PMC3290994 |
| Grant List | R01AI072581 / AI / NIAID NIH HHS / United States R01DK088107 / DK / NIDDK NIH HHS / United States R01CA134530 / CA / NCI NIH HHS / United States R01CA132847 / CA / NCI NIH HHS / United States |
Related Faculty:
Jorge Moscat, Ph.D. Maria Diaz-Meco Conde, Ph.D.