Feedback on fat: p62-mTORC1-autophagy connections.

TitleFeedback on fat: p62-mTORC1-autophagy connections.
Publication TypeJournal Article
Year of Publication2011
AuthorsMoscat J, Diaz-Meco MT
JournalCell
Volume147
Issue4
Pagination724-7
Date Published2011 Nov 11
ISSN1097-4172
KeywordsAdaptor Proteins, Signal Transducing, Adipogenesis, Animals, Autophagy, Homeostasis, Humans, Inflammation, Metabolic Diseases, Mice, Multiprotein Complexes, Transcription Factors
Abstract

Metabolic homeostasis requires integration of multiple signals and cellular activities. Without this integration, conditions of obesity and diabetes often develop. Recent in vivo studies explore the molecular basis for metabolic homestasis, showing that p62 links autophagy and mTORC1 activation to regulate adipogenesis and energy control.

DOI10.1016/j.cell.2011.10.021
Alternate JournalCell
PubMed ID22078874
PubMed Central IDPMC3290994
Grant ListR01AI072581 / AI / NIAID NIH HHS / United States
R01DK088107 / DK / NIDDK NIH HHS / United States
R01CA134530 / CA / NCI NIH HHS / United States
R01CA132847 / CA / NCI NIH HHS / United States
Related Faculty: 
Jorge Moscat, Ph.D. Maria Diaz-Meco Conde, Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700