Title | Enhancement of human immunodeficiency virus type 1-specific CD4 and CD8 T cell responses in chronically infected persons after temporary treatment interruption. |
Publication Type | Journal Article |
Year of Publication | 2000 |
Authors | Papasavvas E, Ortiz GM, Gross R, Sun J, Moore EC, Heymann JJ, Moonis M, Sandberg JK, Drohan LA, Gallagher B, Shull J, Nixon DF, Kostman JR, Montaner LJ |
Journal | J Infect Dis |
Volume | 182 |
Issue | 3 |
Pagination | 766-75 |
Date Published | 2000 Sep |
ISSN | 0022-1899 |
Keywords | Adult, Anti-HIV Agents, CD4-Positive T-Lymphocytes, CD8-Positive T-Lymphocytes, Drug Administration Schedule, Female, HIV Infections, HIV-1, Humans, Immunity, Cellular, Interferon-gamma, Longitudinal Studies, Male, Middle Aged, Viral Load |
Abstract | Immunologic and virologic outcomes of treatment interruption were compared for 5 chronically human immunodeficiency virus (HIV)-infected persons who have maintained antiretroviral therapy-mediated virus suppression, as compared with 5 untreated controls. After a median interruption of 55 days of therapy accompanied by rebound of virus, reinitiated therapy in 4 of 5 subjects resulted in suppression of 98.86% of plasma virus load by 21-33 days and no significant decrease in CD4 T cell percentage from baseline. Increased T helper responses against HIV-1 p24 antigen (P=. 014) and interferon-gamma-secreting CD8 T cell responses against HIV-1 Env (P=.004) were present during interruption of therapy and after reinitiation of treatment. The remaining subject whose treatment was interrupted did not resume treatment and continued to have a low virus load (<1080 HIV-1 RNA copies/mL) and persistent antiviral cell-mediated responses. In summary, cellular immunity against autologous HIV-1 has the potential to be acutely augmented in association with temporary treatment interruption in chronically infected persons. |
DOI | 10.1086/315748 |
Alternate Journal | J Infect Dis |
PubMed ID | 10950770 |
Grant List | AI44595 / AI / NIAID NIH HHS / United States F31GM20068 / GM / NIGMS NIH HHS / United States GM0773 / GM / NIGMS NIH HHS / United States |
Related Faculty:
Jonas Heymann, M.D.