| Title | Drug-associated reversible granulomatous T cell dyscrasia: a distinct subset of the interstitial granulomatous drug reaction. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Magro CM, Cruz-Inigo AE, Votava H, Jacobs M, Wolfe D, A Crowson N |
| Journal | J Cutan Pathol |
| Volume | 37 Suppl 1 |
| Pagination | 96-111 |
| Date Published | 2010 Apr |
| ISSN | 1600-0560 |
| Keywords | Aged, Aged, 80 and over, Angiotensin-Converting Enzyme Inhibitors, Anticonvulsants, Antidepressive Agents, Biopsy, Drug Eruptions, Female, Granuloma, Humans, Lymphoma, T-Cell, Cutaneous, Male, Middle Aged, Precancerous Conditions, Skin Neoplasms, T-Lymphocytes |
| Abstract | BACKGROUND: A cutaneous T-cell infiltrate exhibiting cytologic and architectural atypia, an aberrant phenotypic profile and clonal restriction would fall under the rubric of a T-cell dyscrasia. Although such an infiltrate could represent a lymphoma, this constellation of findings can also be seen in drug-associated pseudolymphoma. METHODS: In 2001, two of the authors (CMM and AEC) proposed the term reversible T-cell dyscrasia to describe atypical T-lymphocytic infiltrates that manifest a light microscopic, phenotypic and molecular profile that closely parallels cutaneous T-cell lymphoma but regress when the causal drug is withdrawn. RESULTS: Herein we report our 10 cases of drug-associated pseudolymphoma resembling granulomatous mycosis fungoides. CONCLUSIONS: We term this reaction pattern drug-associated reversible granulomatous T-cell dyscrasia and consider it a distinct subset of the interstitial granulomatous drug reaction. |
| DOI | 10.1111/j.1600-0560.2010.01518.x |
| Alternate Journal | J Cutan Pathol |
| PubMed ID | 20482682 |
Related Faculty:
Cynthia M. Magro, M.D.