Title | Deconstructing tumor heterogeneity: the stromal perspective. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Vickman RE, Faget DV, Beachy P, Beebe D, Bhowmick NA, Cukierman E, Deng W-M, Granneman JG, Hildesheim J, Kalluri R, Lau KS, Lengyel E, Lundeberg J, Moscat J, Nelson PS, Pietras K, Politi K, Puré E, Scherz-Shouval R, Sherman MH, Tuveson D, Weeraratna AT, White RM, Wong MH, Woodhouse EC, Zheng Y, Hayward SW, Stewart SA |
Journal | Oncotarget |
Volume | 11 |
Issue | 40 |
Pagination | 3621-3632 |
Date Published | 2020 Oct 06 |
ISSN | 1949-2553 |
Abstract | Significant advances have been made towards understanding the role of immune cell-tumor interplay in either suppressing or promoting tumor growth, progression, and recurrence, however, the roles of additional stromal elements, cell types and/or cell states remain ill-defined. The overarching goal of this NCI-sponsored workshop was to highlight and integrate the critical functions of non-immune stromal components in regulating tumor heterogeneity and its impact on tumor initiation, progression, and resistance to therapy. The workshop explored the opposing roles of tumor supportive suppressive stroma and how cellular composition and function may be altered during disease progression. It also highlighted microenvironment-centered mechanisms dictating indolence or aggressiveness of early lesions and how spatial geography impacts stromal attributes and function. The prognostic and therapeutic implications as well as potential vulnerabilities within the heterogeneous tumor microenvironment were also discussed. These broad topics were included in this workshop as an effort to identify current challenges and knowledge gaps in the field. |
DOI | 10.18632/oncotarget.27736 |
Alternate Journal | Oncotarget |
PubMed ID | 33088423 |
PubMed Central ID | PMC7546755 |
Grant List | R01 CA224381 / CA / NCI NIH HHS / United States R01 CA227789 / CA / NCI NIH HHS / United States UL1 TR001863 / TR / NCATS NIH HHS / United States P30 CA010815 / CA / NCI NIH HHS / United States P30 CA008748 / CA / NCI NIH HHS / United States U01 CA235747 / CA / NCI NIH HHS / United States R01 DK062292 / DK / NIDDK NIH HHS / United States R01 DK103831 / DK / NIDDK NIH HHS / United States P01 CA217805 / CA / NCI NIH HHS / United States P30 DK020572 / DK / NIDDK NIH HHS / United States |
Related Faculty:
Jorge Moscat, Ph.D.