| Title | DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase. |
| Publication Type | Journal Article |
| Year of Publication | 2007 |
| Authors | Lee J, Zhou P |
| Journal | Mol Cell |
| Volume | 26 |
| Issue | 6 |
| Pagination | 775-80 |
| Date Published | 2007 Jun 22 |
| ISSN | 1097-2765 |
| Keywords | Animals, Cell Proliferation, Cell Survival, Cullin Proteins, DNA Repair, DNA-Binding Proteins, Genomic Instability, Humans, Protein Processing, Post-Translational, Ubiquitin |
| Abstract | The CUL4-DDB1 ubiquitin ligase regulates cell proliferation, survival, DNA repair, and genomic integrity through targeted ubiquitination of key regulators, yet the substrate receptors that dictate the specificity of this ubiquitination machinery have been largely unknown. Recent work identified a family of DDB1 and CUL4-associated factors (DCAFs) as substrate receptors, implicating a broad spectrum of cellular processes regulated by CUL4-DDB1. |
| DOI | 10.1016/j.molcel.2007.06.001 |
| Alternate Journal | Mol Cell |
| PubMed ID | 17588513 |
Related Lab:
Related Faculty:
Pengbo Zhou, Ph.D.