Title | The complexity of the serine glycine one-carbon pathway in cancer. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Reina-Campos M, Diaz-Meco MT, Moscat J |
Journal | J Cell Biol |
Volume | 219 |
Issue | 1 |
Date Published | 2020 01 06 |
ISSN | 1540-8140 |
Keywords | Animals, Carbon, Glycine, Humans, Metabolic Networks and Pathways, Neoplasms, Serine |
Abstract | The serine glycine and one-carbon pathway (SGOCP) is a crucially important metabolic network for tumorigenesis, of unanticipated complexity, and with implications in the clinic. Solving how this network is regulated is key to understanding the underlying mechanisms of tumor heterogeneity and therapy resistance. Here, we review its role in cancer by focusing on key enzymes with tumor-promoting functions and important products of the SGOCP that are of physiological relevance for tumorigenesis. We discuss the regulatory mechanisms that coordinate the metabolic flux through the SGOCP and their deregulation, as well as how the actions of this metabolic network affect other cells in the tumor microenvironment, including endothelial and immune cells. |
DOI | 10.1083/jcb.201907022 |
Alternate Journal | J Cell Biol |
PubMed ID | 31690618 |
PubMed Central ID | PMC7039202 |
Grant List | R01 DK108743 / DK / NIDDK NIH HHS / United States R01 CA211794 / CA / NCI NIH HHS / United States P30 CA030199 / CA / NCI NIH HHS / United States R01 CA207177 / CA / NCI NIH HHS / United States R01 CA192642 / CA / NCI NIH HHS / United States R01 CA218254 / CA / NCI NIH HHS / United States |
Related Faculty:
Maria Diaz-Meco Conde, Ph.D.