The complexity of the serine glycine one-carbon pathway in cancer.

TitleThe complexity of the serine glycine one-carbon pathway in cancer.
Publication TypeJournal Article
Year of Publication2020
AuthorsReina-Campos M, Diaz-Meco MT, Moscat J
JournalJ Cell Biol
Volume219
Issue1
Date Published2020 01 06
ISSN1540-8140
KeywordsAnimals, Carbon, Glycine, Humans, Metabolic Networks and Pathways, Neoplasms, Serine
Abstract

The serine glycine and one-carbon pathway (SGOCP) is a crucially important metabolic network for tumorigenesis, of unanticipated complexity, and with implications in the clinic. Solving how this network is regulated is key to understanding the underlying mechanisms of tumor heterogeneity and therapy resistance. Here, we review its role in cancer by focusing on key enzymes with tumor-promoting functions and important products of the SGOCP that are of physiological relevance for tumorigenesis. We discuss the regulatory mechanisms that coordinate the metabolic flux through the SGOCP and their deregulation, as well as how the actions of this metabolic network affect other cells in the tumor microenvironment, including endothelial and immune cells.

DOI10.1083/jcb.201907022
Alternate JournalJ Cell Biol
PubMed ID31690618
PubMed Central IDPMC7039202
Grant ListR01 DK108743 / DK / NIDDK NIH HHS / United States
R01 CA211794 / CA / NCI NIH HHS / United States
P30 CA030199 / CA / NCI NIH HHS / United States
R01 CA207177 / CA / NCI NIH HHS / United States
R01 CA192642 / CA / NCI NIH HHS / United States
R01 CA218254 / CA / NCI NIH HHS / United States
Related Faculty: 
Maria Diaz-Meco Conde, Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700