Title | Clonal light chain restricted primary intrapulmonary nodular amyloidosis. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Ross P, Magro CM |
Journal | Ann Thorac Surg |
Volume | 80 |
Issue | 1 |
Pagination | 344-7 |
Date Published | 2005 Jul |
ISSN | 1552-6259 |
Keywords | Aged, Amyloidosis, Female, Humans, Immunoglobulin Light Chains, Lung Diseases, Middle Aged, Paraproteinemias, Pneumonectomy |
Abstract | Primary intrapulmonary nodular amyloidosis is a rare form of immunoglobulin associated amyloidosis, also falling under the alternative appellation of amyloidoma. Although amyloidomas in other organ sites may be reflective of a localized or more generalized plasma cell dyscrasia, in the context of its presentation in the lung the presumptive basis has long been held to be one of chronic inflammation. We encountered 2 patients with nodular amyloidosis in whom the pathologic examination disclosed the basis to be one of a light chain restricted clonal lymphocytic plasma cell infiltrate, although without morphologic features of coexisting pulmonary lymphoma. These 2 patients serve to underscore the potential categorization of some cases of pulmonary nodular amyloidosis as a form of low grade B cell lymphoproliferative disease. |
DOI | 10.1016/j.athoracsur.2004.03.075 |
Alternate Journal | Ann Thorac Surg |
PubMed ID | 15975406 |
Related Faculty:
Cynthia M. Magro, M.D.