| Title | Brincidofovir for polyomavirus-associated nephropathy after allogeneic hematopoietic stem cell transplantation. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Papanicolaou GA, Lee YJoo, Young JW, Seshan SV, Boruchov AM, Chittick G, Momméja-Marin H, Glezerman IG |
| Journal | Am J Kidney Dis |
| Volume | 65 |
| Issue | 5 |
| Pagination | 780-4 |
| Date Published | 2015 May |
| ISSN | 1523-6838 |
| Keywords | BK Virus, Cytomegalovirus Infections, Cytosine, Hematopoietic Stem Cell Transplantation, Humans, Immunocompromised Host, Kidney Diseases, Male, Middle Aged, Organophosphonates, Polyomavirus, Polyomavirus Infections, Tumor Virus Infections, Viremia |
| Abstract | Polyomavirus-associated nephropathy (PVAN) is common in patients who have undergone kidney transplantation and has been reported in hematopoietic stem cell (HSC) transplant recipients. Aside from reduction of immunosuppression, few therapeutic options exist for treatment of PVAN. We report a case of PVAN in a severely immunocompromised allogeneic HSC transplant recipient that was treated with brincidofovir without reduction of immunosuppression. We review our institutional experience of PVAN in HSC transplantation and discuss the potential use of brincidofovir for treatment. |
| DOI | 10.1053/j.ajkd.2014.11.020 |
| Alternate Journal | Am J Kidney Dis |
| PubMed ID | 25600489 |
| PubMed Central ID | PMC5916792 |
| Grant List | P30 CA008748 / CA / NCI NIH HHS / United States |
Related Faculty:
Surya V. Seshan, M.D.