Title | Bone marrow metastasis of prostatic adenocarcinoma with post-treatment foamy-like changes: A diagnostic pitfall. |
Publication Type | Journal Article |
Year of Publication | 2014 |
Authors | Yigit N, Geyer JTurbiner |
Journal | Can Urol Assoc J |
Volume | 8 |
Issue | 11-12 |
Pagination | E941-3 |
Date Published | 2014 Nov |
ISSN | 1911-6470 |
Abstract | Prostatic acinar adenocarcinoma (PAA) is the most common malignant tumour of the male genital system. Hormonal therapy and radiotherapy are widely-used treatment modalities in advanced stage disease. However, with hormonal therapy, the morphology of the neoplastic cells can be altered with a shift towards benign-appearing cells with inconspicuous nucleoli and abundant cytoplasm. When the tumour spreads to the bone marrow, these neoplastic cells can mimic foamy histiocytes, which may lead to a misdiagnosis. This becomes more challenging if a concurrent bone marrow malignancy is identified. Attention should be paid if foamy cells are detected in bone marrow, particularly if the patient has a history of PAA. To the best of our knowledge, this is the first report of simultaneous bone marrow involvement by metastatic PAA with mimicking foamy histiocytes and lymphoplasmacytic lymphoma. |
DOI | 10.5489/cuaj.2402 |
Alternate Journal | Can Urol Assoc J |
PubMed ID | 25553175 |
PubMed Central ID | PMC4277542 |
Related Faculty:
Julia Geyer, M.D.