| Title | BCR-PDGFRA fusion in a T lymphoblastic leukemia/lymphoma. |
| Publication Type | Journal Article |
| Year of Publication | 2015 |
| Authors | Yigit N, Wu WW, Subramaniyam S, Mathew S, Geyer JT |
| Journal | Cancer Genet |
| Volume | 208 |
| Issue | 7-8 |
| Pagination | 404-7 |
| Date Published | 2015 Jul-Aug |
| ISSN | 2210-7762 |
| Keywords | Chromosome Banding, Chromosomes, Human, Pair 22, Chromosomes, Human, Pair 4, Humans, In Situ Hybridization, Fluorescence, Karyotype, Male, Middle Aged, Oncogene Proteins, Fusion, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Proto-Oncogene Proteins c-bcr, Receptor, Platelet-Derived Growth Factor alpha, Translocation, Genetic |
| Abstract | The BCR-PDGFRA fusion is a very rare event. To date, only eight cases of hematolymphoid neoplasms with the BCR-PDGFRA fusion gene have been reported. All cases except one had eosinophilia. We present the first case of T acute lymphoblastic leukemia with a t(4;22)(q12;q11.2) involving the BCR and PDGFRA genes, without associated eosinophilia. Radiology showed splenomegaly and extensive lymph node involvement. The patient rapidly achieved complete remission with treatment protocol for Philadelphia chromosome-negative acute lymphoblastic leukemia. |
| DOI | 10.1016/j.cancergen.2015.04.007 |
| Alternate Journal | Cancer Genet |
| PubMed ID | 26095243 |
Related Faculty:
Julia Geyer, M.D.