BCR-PDGFRA fusion in a T lymphoblastic leukemia/lymphoma.

TitleBCR-PDGFRA fusion in a T lymphoblastic leukemia/lymphoma.
Publication TypeJournal Article
Year of Publication2015
AuthorsYigit N, Wu WW, Subramaniyam S, Mathew S, Geyer JT
JournalCancer Genet
Volume208
Issue7-8
Pagination404-7
Date Published2015 Jul-Aug
ISSN2210-7762
KeywordsChromosome Banding, Chromosomes, Human, Pair 22, Chromosomes, Human, Pair 4, Humans, In Situ Hybridization, Fluorescence, Karyotype, Male, Middle Aged, Oncogene Proteins, Fusion, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Proto-Oncogene Proteins c-bcr, Receptor, Platelet-Derived Growth Factor alpha, Translocation, Genetic
Abstract

The BCR-PDGFRA fusion is a very rare event. To date, only eight cases of hematolymphoid neoplasms with the BCR-PDGFRA fusion gene have been reported. All cases except one had eosinophilia. We present the first case of T acute lymphoblastic leukemia with a t(4;22)(q12;q11.2) involving the BCR and PDGFRA genes, without associated eosinophilia. Radiology showed splenomegaly and extensive lymph node involvement. The patient rapidly achieved complete remission with treatment protocol for Philadelphia chromosome-negative acute lymphoblastic leukemia.

DOI10.1016/j.cancergen.2015.04.007
Alternate JournalCancer Genet
PubMed ID26095243
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