| Title | Activity of Imipenem-Relebactam and Comparator Agents against Genetically Characterized Isolates of Carbapenem-Resistant Enterobacteriaceae. |
| Publication Type | Journal Article |
| Year of Publication | 2019 |
| Authors | Canver MC, Satlin MJ, Westblade LF, Kreiswirth BN, Chen L, Robertson A, Fauntleroy K, La Spina M, Callan K, Jenkins SG |
| Journal | Antimicrob Agents Chemother |
| Volume | 63 |
| Issue | 9 |
| Date Published | 2019 09 |
| ISSN | 1098-6596 |
| Keywords | Anti-Bacterial Agents, Azabicyclo Compounds, Bacteremia, beta-Lactamases, Carbapenem-Resistant Enterobacteriaceae, Ceftazidime, Drug Combinations, Enterobacteriaceae Infections, Humans, Imipenem, Klebsiella pneumoniae, Microbial Sensitivity Tests |
| Abstract | Carbapenem-resistant (CRE) strains are an urgent public health threat. We evaluated the activities of 19 antimicrobial agents, including imipenem-relebactam, against (i) 106 CRE bloodstream isolates that primarily expressed carbapenemase (KPC) and (ii) 20 OXA-48-like-expressing CRE isolates. Ninety-five percent of CRE bloodstream isolates were susceptible to imipenem-relebactam. In contrast to their comparable activities against KPC-producing CRE strains, ceftazidime-avibactam was more active against OXA-48-like CRE strains than was imipenem-relebactam (90% susceptible versus 15% susceptible). |
| DOI | 10.1128/AAC.00672-19 |
| Alternate Journal | Antimicrob Agents Chemother |
| PubMed ID | 31262761 |
| PubMed Central ID | PMC6709495 |
| Grant List | R01 AI090155 / AI / NIAID NIH HHS / United States |
Related Faculty:
Lars Westblade, Ph.D.