Title | Concomitant calciphylaxis and COVID-19 associated thrombotic retiform purpura. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Rotman JA, Dean KE, Magro C, Nuovo G, Bartolotta RJ |
Journal | Skeletal Radiol |
Volume | 49 |
Issue | 11 |
Pagination | 1879-1884 |
Date Published | 2020 Nov |
ISSN | 1432-2161 |
Keywords | Betacoronavirus, Calciphylaxis, Computed Tomography Angiography, Coronavirus Infections, COVID-19, Diagnosis, Differential, Fatal Outcome, Female, Humans, Lower Extremity, Middle Aged, Pandemics, Pneumonia, Viral, Polymerase Chain Reaction, Purpura, SARS-CoV-2, Ultrasonography |
Abstract | While initial reports regarding coronavirus disease 2019 (COVID-19) focused on its pulmonary manifestations, more recent literature describes multisystem abnormalities related to its associated microvascular angiopathy. Calciphylaxis is a rare systemic condition characterized by tissue necrosis in the setting of systemic microvascular calcifications. Both COVID-19 and calciphylaxis are procoagulant diagnoses associated with vascular-mediated cutaneous findings. To our knowledge, this is the first report to document the coexistence of COVID-19 associated retiform thrombotic purpura and calciphylaxis in a single patient, to link the pathologic etiologies of the two entities, and to describe the concomitant diagnoses' associated radiologic findings. |
DOI | 10.1007/s00256-020-03579-6 |
Alternate Journal | Skeletal Radiol |
PubMed ID | 32844243 |
PubMed Central ID | PMC7447529 |
Related Faculty:
Cynthia M. Magro, M.D.