Concomitant calciphylaxis and COVID-19 associated thrombotic retiform purpura.

TitleConcomitant calciphylaxis and COVID-19 associated thrombotic retiform purpura.
Publication TypeJournal Article
Year of Publication2020
AuthorsRotman JA, Dean KE, Magro C, Nuovo G, Bartolotta RJ
JournalSkeletal Radiol
Volume49
Issue11
Pagination1879-1884
Date Published2020 Nov
ISSN1432-2161
KeywordsBetacoronavirus, Calciphylaxis, Computed Tomography Angiography, Coronavirus Infections, COVID-19, Diagnosis, Differential, Fatal Outcome, Female, Humans, Lower Extremity, Middle Aged, Pandemics, Pneumonia, Viral, Polymerase Chain Reaction, Purpura, SARS-CoV-2, Ultrasonography
Abstract

While initial reports regarding coronavirus disease 2019 (COVID-19) focused on its pulmonary manifestations, more recent literature describes multisystem abnormalities related to its associated microvascular angiopathy. Calciphylaxis is a rare systemic condition characterized by tissue necrosis in the setting of systemic microvascular calcifications. Both COVID-19 and calciphylaxis are procoagulant diagnoses associated with vascular-mediated cutaneous findings. To our knowledge, this is the first report to document the coexistence of COVID-19 associated retiform thrombotic purpura and calciphylaxis in a single patient, to link the pathologic etiologies of the two entities, and to describe the concomitant diagnoses' associated radiologic findings.

DOI10.1007/s00256-020-03579-6
Alternate JournalSkeletal Radiol
PubMed ID32844243
PubMed Central IDPMC7447529
Related Faculty: 
Cynthia M. Magro, M.D.

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