Title | Subclinical chronic lymphocytic leukaemia associated with a 13q deletion presenting initially in the skin: apropos of a case. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Khandelwal A, Seilstad KH, Magro CM |
Journal | J Cutan Pathol |
Volume | 33 |
Issue | 3 |
Pagination | 256-9 |
Date Published | 2006 Mar |
ISSN | 0303-6987 |
Keywords | Aged, Biomarkers, Tumor, Carcinoma, Squamous Cell, Chromosome Deletion, Chromosomes, Human, Pair 13, Humans, Leukemia, Lymphocytic, Chronic, B-Cell, Male, Neoplasms, Second Primary, Skin Neoplasms, Spectral Karyotyping |
Abstract | INTRODUCTION: B-cell chronic lymphocytic leukaemia (B-CLL) represents a low-grade B-cell lymphoproliferative disease that is the most common leukaemia in adults. The neoplastic cell is an autoreactive CD5 CD23 B lymphocyte. B-CLL may involve the skin, typically in the context of known disease. We present a case of subclinical B-CLL presenting initially in the skin. CASE REPORT: A 73-year-old male developed a lesion on his right cheek in April 2003 compatible with basal cell carcinoma. The re-excision specimen contained a well-differentiated atypical lymphocytic infiltrate consistent with B-CLL along with residual carcinoma. Subsequent laboratory studies revealed peripheral blood lymphocytosis with smudge cells. A diagnosis was made of Rai stage 0 CLL. Chromosomal studies on peripheral blood showed a deletion at 13q14.3. Excision of a second primary skin carcinoma revealed a squamous cell carcinoma in association with B-CLL that was identical to his previously diagnosed skin involvement. CONCLUSION: This case identifies a cutaneous presentation of subclinical B-CLL. There are two prior reports describing B-CLL presenting initially in the skin. In one case, the infiltrates were incidental on a re-excision specimen. The second report suggests 16% of B-CLL patients have cutaneous manifestations as the first sign of disease. |
DOI | 10.1111/j.0303-6987.2006.00430.x |
Alternate Journal | J Cutan Pathol |
PubMed ID | 16466516 |
Related Faculty:
Cynthia M. Magro, M.D.