"Stromal cells in prostate cancer pathobiology: friends or foes?".

Title"Stromal cells in prostate cancer pathobiology: friends or foes?".
Publication TypeJournal Article
Year of Publication2023
AuthorsPederzoli F, Raffo M, Pakula H, Ravera F, Nuzzo PVitale, Loda M
JournalBr J Cancer
Date Published2023 Apr
KeywordsCell Transformation, Neoplastic, Epithelial Cells, Humans, Male, Prostate, Prostatic Neoplasms, Stromal Cells, Tumor Microenvironment

The genomic, epigenetic and metabolic determinants of prostate cancer pathobiology have been extensively studied in epithelial cancer cells. However, malignant cells constantly interact with the surrounding environment-the so-called tumour microenvironment (TME)-which may influence tumour cells to proliferate and invade or to starve and die. In that regard, stromal cells-including fibroblasts, smooth muscle cells and vasculature-associated cells-constitute an essential fraction of the prostate cancer TME. However, they have been largely overlooked compared to other cell types (i.e. immune cells). Indeed, their importance in prostate physiology starts at organogenesis, as the soon-to-be prostate stroma determines embryonal epithelial cells to commit toward prostatic differentiation. Later in life, the appearance of a reactive stroma is linked to the malignant transformation of epithelial cells and cancer progression. In this Review, we discuss the main mesenchymal cell populations of the prostate stroma, highlighting their dynamic role in the transition of the healthy prostate epithelium to cancer. A thorough understanding of those populations, their phenotypes and their transcriptional programs may improve our understanding of prostate cancer pathobiology and may help to exploit prostate stroma as a biomarker of patient stratification and as a therapeutic target.

Alternate JournalBr J Cancer
PubMed ID36482187
PubMed Central IDPMC10006214
Grant ListP01 CA265768 / CA / NCI NIH HHS / United States
P50 CA211024 / CA / NCI NIH HHS / United States
Related Faculty: 
Massimo Loda, M.D. Pier Nuzzo, Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
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