Spindle cell tumors of the pleura and the peritoneum: pathologic diagnosis and updates.

TitleSpindle cell tumors of the pleura and the peritoneum: pathologic diagnosis and updates.
Publication TypeJournal Article
Year of Publication2022
AuthorsBoyraz B, Hung YP
JournalAPMIS
Volume130
Issue3
Pagination140-154
Date Published2022 Mar
ISSN1600-0463
KeywordsHumans, Peritoneum, Pleura, Pleural Neoplasms, Prognosis, Sarcoma
Abstract

A diverse group of both benign and malignant spindle cell tumors can involve the pleura or the peritoneum. Due to their rarity and overlapping morphologic features, these tumors can pose considerable diagnostic difficulty in surgical pathology. As these tumors differ in their prognosis and clinical management, their correct pathologic diagnosis is critical. In addition to histologic assessment, select immunohistochemical and molecular tools can aid the distinction among these tumors. In this review, we consider some of the major histologic differential diagnosis of spindle cell tumors involving these serosal membranes. This list of tumors includes solitary fibrous tumor, inflammatory myofibroblastic tumor, desmoid fibromatosis, synovial sarcoma, sarcomatoid carcinoma, spindle cell melanoma, dedifferentiated liposarcoma, epithelioid hemangioendothelioma, and sarcomatoid mesothelioma. We describe their salient clinicopathologic and genetic findings, with a review on some of the recent discoveries on their molecular pathogenesis.

DOI10.1111/apm.13203
Alternate JournalAPMIS
PubMed ID34942046
Related Faculty: 
Baris Boyraz, M.D., Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700