Something Old and Something New to Unleash the Power of Natural Killer Cells against Metastases.

TitleSomething Old and Something New to Unleash the Power of Natural Killer Cells against Metastases.
Publication TypeJournal Article
Year of Publication2022
AuthorsDemaria S
JournalCancer Immunol Res
Volume10
Issue1
Pagination3
Date Published2022 Jan
ISSN2326-6074
KeywordsAnimals, Humans, Immunotherapy, Killer Cells, Natural, Lung Neoplasms, Mice, Neoadjuvant Therapy, Triple Negative Breast Neoplasms
Abstract

Single-agent immunotherapy has improved outcomes for patients with cancer, but only a minority of patients respond, necessitating investigation of combinations of immunotherapy agents. In this issue of Cancer Immunology Research, Milling and colleagues show that neoadjuvant therapy with an intratumoral stimulator of interferon genes agonist combined with systemic IL2 and anti-PD-1 results in clearance of lung metastases mediated by natural killer cells in mouse models of triple-negative breast cancer.See related article by Milling et al., p. 26. (4).

DOI10.1158/2326-6066.CIR-21-0948
Alternate JournalCancer Immunol Res
PubMed ID34815266
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