| Title | Small Biopsy and Cytology of Pulmonary Neuroendocrine Neoplasms: Brief Overview of Classification, Immunohistochemistry, Molecular Profiles, and World Health Organization Updates. |
| Publication Type | Journal Article |
| Year of Publication | 2022 |
| Authors | Sung S, Heymann JJ, Politis MGarlin, Baine MK, Rekhtman N, Saqi A |
| Journal | Adv Anat Pathol |
| Volume | 29 |
| Issue | 6 |
| Pagination | 329-336 |
| Date Published | 2022 Nov 01 |
| ISSN | 1533-4031 |
| Keywords | Biopsy, Carcinoid Tumor, Carcinoma, Neuroendocrine, Humans, Immunohistochemistry, Lung Neoplasms, Neuroendocrine Tumors, World Health Organization |
| Abstract | Pulmonary neuroendocrine neoplasms comprise ~20% of all lung tumors. Typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma represent the 4 major distinct subtypes recognized on resections. This review provides a brief overview of the cytomorphologic features and the 2021 World Health Organization classification of these tumor types on small biopsy and cytology specimens. Also discussed are the role of immunohistochemistry in the diagnosis and molecular signatures of pulmonary neuroendocrine tumors. |
| DOI | 10.1097/PAP.0000000000000360 |
| Alternate Journal | Adv Anat Pathol |
| PubMed ID | 36053019 |
Related Faculty:
Jonas Heymann, M.D.