Small Biopsy and Cytology of Pulmonary Neuroendocrine Neoplasms: Brief Overview of Classification, Immunohistochemistry, Molecular Profiles, and World Health Organization Updates.

TitleSmall Biopsy and Cytology of Pulmonary Neuroendocrine Neoplasms: Brief Overview of Classification, Immunohistochemistry, Molecular Profiles, and World Health Organization Updates.
Publication TypeJournal Article
Year of Publication2022
AuthorsSung S, Heymann JJ, Politis MGarlin, Baine MK, Rekhtman N, Saqi A
JournalAdv Anat Pathol
Volume29
Issue6
Pagination329-336
Date Published2022 Nov 01
ISSN1533-4031
KeywordsBiopsy, Carcinoid Tumor, Carcinoma, Neuroendocrine, Humans, Immunohistochemistry, Lung Neoplasms, Neuroendocrine Tumors, World Health Organization
Abstract

Pulmonary neuroendocrine neoplasms comprise ~20% of all lung tumors. Typical carcinoid, atypical carcinoid, small cell carcinoma, and large cell neuroendocrine carcinoma represent the 4 major distinct subtypes recognized on resections. This review provides a brief overview of the cytomorphologic features and the 2021 World Health Organization classification of these tumor types on small biopsy and cytology specimens. Also discussed are the role of immunohistochemistry in the diagnosis and molecular signatures of pulmonary neuroendocrine tumors.

DOI10.1097/PAP.0000000000000360
Alternate JournalAdv Anat Pathol
PubMed ID36053019
Related Faculty: 
Jonas Heymann, M.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700