| Title | Role of leukocyte influx in tissue prostaglandin H synthase-2 overexpression induced by phorbol ester and arachidonic acid in skin. |
| Publication Type | Journal Article |
| Year of Publication | 1999 |
| Authors | Sanchez T, Moreno JJ |
| Journal | Biochem Pharmacol |
| Volume | 58 |
| Issue | 5 |
| Pagination | 877-9 |
| Date Published | 1999 Sep 01 |
| ISSN | 0006-2952 |
| Keywords | Acute Disease, Animals, Arachidonic Acid, Biological Transport, Carcinogens, Chemotaxis, Leukocyte, Cyclooxygenase 2, Dermatitis, Dermatologic Agents, Edema, Isoenzymes, Leukocytes, Mice, Prostaglandin-Endoperoxide Synthases, Skin, Tetradecanoylphorbol Acetate |
| Abstract | The accumulation of neutrophils and mononuclear cells is a characteristic feature of 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced ear edema. This cell influx was accompanied by the enhancement of eicosanoid tissue levels and prostaglandin H synthase-2 (PGHS-2) overexpression. Sialidase treatment, which affects the structure of selectins and inhibits leukocyte influx, significantly reduced eicosanoid and PGHS-2 levels and edema. In contrast, skin PGHS-2 overexpression induced by arachidonic acid (AA) application was not affected by sialidase treatment. These results suggest that PGHS-2 overexpression induced by TPA could be induced by AA and/or AA metabolite release by leukocyte infiltrated during the inflammatory process. |
| DOI | 10.1016/s0006-2952(99)00169-0 |
| Alternate Journal | Biochem Pharmacol |
| PubMed ID | 10449199 |
Related Faculty:
Teresa Sanchez, Ph.D.