Title | Role of diet in prostate cancer: the epigenetic link. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Labbé DP, Zadra G, Ebot EM, Mucci LA, Kantoff PW, Loda M, Brown M |
Journal | Oncogene |
Volume | 34 |
Issue | 36 |
Pagination | 4683-91 |
Date Published | 2015 Sep 03 |
ISSN | 1476-5594 |
Keywords | Acetylation, DNA Methylation, Epigenesis, Genetic, Genome, Human, Histone Code, Humans, Male, Prostatic Neoplasms, Risk Factors |
Abstract | Diet is hypothesized to be a critical environmentally related risk factor for prostate cancer (PCa) development, and specific diets and dietary components can also affect PCa progression; however, the mechanisms underlying these associations remain elusive. As for a maturing organism, PCa's epigenome is plastic and evolves from the pre-neoplastic to the metastatic stage. In particular, epigenetic remodeling relies on substrates or cofactors obtained from the diet. Here we review the evidence that bridges dietary modulation to alterations in the prostate epigenome. We propose that such diet-related effects offer a mechanistic link between the impact of different diets and the course of PCa development and progression. |
DOI | 10.1038/onc.2014.422 |
Alternate Journal | Oncogene |
PubMed ID | 25531313 |
PubMed Central ID | PMC4476943 |
Grant List | / CAPMC / CIHR / Canada P01 CA163227 / CA / NCI NIH HHS / United States R01 CA131945 / CA / NCI NIH HHS / United States 1P01CA163227 / CA / NCI NIH HHS / United States P50 CA090381 / CA / NCI NIH HHS / United States P50CA090381 / CA / NCI NIH HHS / United States |
Related Faculty:
Massimo Loda, M.D.