Role of diet in prostate cancer: the epigenetic link.

TitleRole of diet in prostate cancer: the epigenetic link.
Publication TypeJournal Article
Year of Publication2015
AuthorsLabbé DP, Zadra G, Ebot EM, Mucci LA, Kantoff PW, Loda M, Brown M
JournalOncogene
Volume34
Issue36
Pagination4683-91
Date Published2015 Sep 03
ISSN1476-5594
KeywordsAcetylation, DNA Methylation, Epigenesis, Genetic, Genome, Human, Histone Code, Humans, Male, Prostatic Neoplasms, Risk Factors
Abstract

Diet is hypothesized to be a critical environmentally related risk factor for prostate cancer (PCa) development, and specific diets and dietary components can also affect PCa progression; however, the mechanisms underlying these associations remain elusive. As for a maturing organism, PCa's epigenome is plastic and evolves from the pre-neoplastic to the metastatic stage. In particular, epigenetic remodeling relies on substrates or cofactors obtained from the diet. Here we review the evidence that bridges dietary modulation to alterations in the prostate epigenome. We propose that such diet-related effects offer a mechanistic link between the impact of different diets and the course of PCa development and progression.

DOI10.1038/onc.2014.422
Alternate JournalOncogene
PubMed ID25531313
PubMed Central IDPMC4476943
Grant List / CAPMC / CIHR / Canada
P01 CA163227 / CA / NCI NIH HHS / United States
R01 CA131945 / CA / NCI NIH HHS / United States
1P01CA163227 / CA / NCI NIH HHS / United States
P50 CA090381 / CA / NCI NIH HHS / United States
P50CA090381 / CA / NCI NIH HHS / United States
Related Faculty: 
Massimo Loda, M.D.

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