Title | Reduction of circulating annexin A5 levels and resistance to annexin A5 anticoagulant activity in women with recurrent spontaneous pregnancy losses. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Rand JH, Arslan AA, Wu X-X, Wein R, Mulholland J, Shah M, van Heerde WL, Reutelingsperger CP, Lockwood CJ, Kuczynski E |
Journal | Am J Obstet Gynecol |
Volume | 194 |
Issue | 1 |
Pagination | 182-8 |
Date Published | 2006 Jan |
ISSN | 1097-6868 |
Keywords | Abortion, Habitual, Adult, Annexin A5, Antibodies, Antibodies, Anticardiolipin, Anticoagulants, Case-Control Studies, Drug Resistance, Female, Humans, Medical Records, Phospholipids, Pregnancy |
Abstract | OBJECTIVE: We investigated whether levels of annexin A5, evidence for resistance to annexin A5 activity, and levels anti-annexin A5 antibodies might be altered in women with a history of recurrent spontaneous pregnancy losses. STUDY DESIGN: These annexin A5 parameters were assayed in 70 nonpregnant women with a history of > or = 3 recurrent spontaneous pregnancy losses (cases) and 50 women without adverse pregnancy history (control subjects). RESULTS: Cases had significantly lower plasma annexin A5 levels than control subjects (median, 4.7 ng/mL [range, 0.3-40.4 ng/mL] vs 6.7 ng/mL [range, 0.7-56.0]; P = .01), significantly reduced anticoagulant ratios (188% [range, 119%-279%] vs 238% [range, 159%-286%]; P < .0001), and reduced binding of annexin A5 to phospholipid (6.3 ng/aliquot phospholipid [range, 1.5-16.4 ng/aliquot phospholipid] vs 9.7 ng/aliquot phospholipid (range, 3.5-17.0 ng/aliquot phospholipid]; P = .0002). There were no significant differences in anti-annexin A5 antibody levels. CONCLUSION: Reduction of annexin A5 and interference with its anticoagulant and binding activities are associated significantly with a history of recurrent spontaneous pregnancy losses. These data support the concept of a significant role for annexin A5 in the maintenance of pregnancy. |
DOI | 10.1016/j.ajog.2005.05.034 |
Alternate Journal | Am J Obstet Gynecol |
PubMed ID | 16389029 |
Grant List | HL-61331 / HL / NHLBI NIH HHS / United States M01 RR00096 / RR / NCRR NIH HHS / United States |
Related Faculty:
Jacob H. Rand, M.D.