Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer.

TitlePrognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer.
Publication TypeJournal Article
Year of Publication1997
AuthorsEsposito V, Baldi A, De Luca A, Groger AM, Loda M, Giordano GG, Caputi M, Baldi F, Pagano M, Giordano A
JournalCancer Res
Date Published1997 Aug 15
KeywordsAdenocarcinoma, Carcinoma, Non-Small-Cell Lung, Carcinoma, Squamous Cell, Cell Cycle Proteins, Cyclin-Dependent Kinase Inhibitor p27, Female, Humans, Lung Neoplasms, Male, Microtubule-Associated Proteins, Middle Aged, Neoplasm Proteins, Prognosis, Survival Analysis, Tumor Suppressor Proteins

Despite its potential role as a tumor suppressor, p27 gene, a member of the Cip/Kip family of cyclin-dependent kinase inhibitor genes, has never been found mutated in human tumors. We investigated p27 protein expression in a series of 108 non-small cell lung cancers (57.4% stage 1, 16.7% stage 2, and 25.9% stage 3) to determine whether the lack or altered expression of this protein correlates with neoplastic transformation and/or progression. We performed immunohistochemistry and Western blot analysis of each specimen. We found that tumors expressing low to undetectable levels of p27 contained high p27 degradation activity. When we evaluated the outcome of the patients in relationship to p27 expression, we found p27 to be a prognostic factor correlating with the overall survival times (P = 0.0012). The possibility of a simple assay, such as the immunohistochemical analysis of p27 expression on routinely formalin-fixed, paraffin-embedded specimens, has considerable value for the prognosis of patients who undergo surgical resection. In addition, confirmation of the involvement of the proteasome-mediated proteolysis in p27 degradation should stimulate new strategies of nonsurgical treatments of non-small cell lung cancer.

Alternate JournalCancer Res
PubMed ID9270000
Grant ListCA662290-02 / CA / NCI NIH HHS / United States
P01 N536466 / / PHS HHS / United States
R01 CA60999-01A1 / CA / NCI NIH HHS / United States
Related Faculty: 
Massimo Loda, M.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
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