Predictors of squamous cell carcinoma in high-risk patients in the VATTC trial.

TitlePredictors of squamous cell carcinoma in high-risk patients in the VATTC trial.
Publication TypeJournal Article
Year of Publication2013
AuthorsXiong MY, Rizzo AE, Cohen TSD, Dyer RK, Korgavkar K, Bingham SF, Weinstock MA
Corporate AuthorsVeterans Affairs Topical Tretinoin Chemoprevention(VATTC) Trial Group
JournalJ Invest Dermatol
Volume133
Issue6
Pagination1521-32
Date Published2013 Jun
ISSN1523-1747
KeywordsAged, Aged, 80 and over, Antineoplastic Agents, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Female, Follow-Up Studies, Humans, Male, Middle Aged, Multivariate Analysis, Predictive Value of Tests, Risk Factors, Skin Neoplasms, Sunburn, Sunscreening Agents, Tretinoin, Veterans, Warts
Abstract

Invasive squamous cell carcinoma (SCC) of the skin is one of the most common cancers in the United States, with no proven means for prevention other than systemic retinoids, which have significant toxicity, and sunscreen. We sought to determine the risk factors for invasive SCC on the face or ears in a high-risk population comprising 1,131 veterans in the Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial. Participants were required to have been diagnosed with at least two keratinocyte carcinomas (KCs) in the 5 years prior to enrollment. The median duration of follow-up was 3.7 years. Twenty-three percent of the participants developed a new invasive SCC, and the cumulative risk of invasive SCC was 30% at 5 years. The following factors independently predicted for new invasive SCCs: number of invasive SCCs and number of in situ SCCs in the 5 years prior to enrollment, actinic keratoses count at enrollment, a history of ever use of topical 5-fluorouracil, and total occupational time spent outdoors. In contrast, the use of angiotensin-convering enzyme inhibitors or angiotensin receptor blockers during the study and a history of warts anywhere on the body were found to protect against new invasive SCCs. These independent predictors remained the same for all SCCs (invasive and in situ combined). The number of basal cell carcinomas in the 5 years prior to enrollment, sunburns, sun sensitivity, and recreational sun exposure were not associated with new SCCs. These findings identify key risk factors for additional SCCs in patients with multiple prior KCs, and suggest that a history of warts may be associated with reduced SCC risk.

DOI10.1038/jid.2013.35
Alternate JournalJ Invest Dermatol
PubMed ID23348836
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Tobias Cohen, M.D., Ph.D.

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