Polyoma (BK) virus associated urothelial carcinoma originating within a renal allograft five years following resolution of polyoma virus nephropathy.

TitlePolyoma (BK) virus associated urothelial carcinoma originating within a renal allograft five years following resolution of polyoma virus nephropathy.
Publication TypeJournal Article
Year of Publication2016
AuthorsSalvatore SP, Myers-Gurevitch PM, Chu S, Robinson BD, Dadhania D, Seshan SV
JournalClin Nephrol
Volume85
Issue3
Pagination179-83
Date Published2016 Mar
ISSN0301-0430
KeywordsAllografts, BK Virus, Carcinoma, Transitional Cell, Cell Transformation, Neoplastic, Cell Transformation, Viral, Diarrhea, Female, Follow-Up Studies, Humans, Kidney Diseases, Kidney Neoplasms, Kidney Transplantation, Middle Aged, Polyomavirus Infections, Tumor Virus Infections, Viremia, Weight Loss
Abstract

A direct role for BK polyomavirus infection in malignant tumors of renal allografts and urinary tract is emerging. Case reports suggest a link between BK virus (BKV) reactivation and development of malignancy in renal allograft recipients. Herein we describe the first case of BKV positive invasive urothelial carcinoma within the renal allograft, presenting with chronic diarrhea and weight loss 5 years following resolution of BK viremia/nephropathy (BKVN). Unique to our case was the remote history of BK viremia/BKVN, rising titer of anti-HLA antibody and presence of renal limited urothelial carcinoma with microinvasion of malignant cells staining positive for SV40 large T antigen (T-Ag). These findings suggest that persistence of subclinical BKV infection within the renal allograft may play a role in the malignant transformation of epithelial cells. Patients with history of BKVN may be at risk for kidney and urinary tract malignancy despite resolution of BK viremia/BKVN.

DOI10.5414/CN108410
Alternate JournalClin Nephrol
PubMed ID26709521
Related Faculty: 
Brian Robinson, M.D. Steven P. Salvatore, M.D. Surya V. Seshan, M.D.

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