Plasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes.

TitlePlasma cells are enriched in localized prostate cancer in Black men and are associated with improved outcomes.
Publication TypeJournal Article
Year of Publication2021
AuthorsWeiner AB, Vidotto T, Liu Y, Mendes AA, Salles DC, Faisal FA, Murali S, McFarlane M, Imada EL, Zhao X, Li Z, Davicioni E, Marchionni L, Chinnaiyan AM, Freedland SJ, Spratt DE, Wu JD, Lotan TL, Schaeffer EM
JournalNat Commun
Volume12
Issue1
Pagination935
Date Published2021 02 10
ISSN2041-1723
KeywordsAfrican Americans, Aged, Cell Movement, Cohort Studies, Humans, Immunoglobulin G, Killer Cells, Natural, Male, Middle Aged, Plasma Cells, Prostate, Prostatic Neoplasms
Abstract

Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune-responsiveness exist for prostate cancer, we explored race-based immune-profiles to identify vulnerabilities. Here we show in multiple independent cohorts comprised of over 1,300 patient samples annotated with either self-identified race or genetic ancestry, prostate tumors from Black men or men of African ancestry have increases in plasma cell infiltrate and augmented markers of NK cell activity and IgG expression. These findings are associated with improved recurrence-free survival following surgery and nominate plasma cells as drivers of prostate cancer immune-responsiveness.

DOI10.1038/s41467-021-21245-w
Alternate JournalNat Commun
PubMed ID33568675
PubMed Central IDPMC7876147
Grant ListR01 CA212409 / CA / NCI NIH HHS / United States
U01 CA196390 / CA / NCI NIH HHS / United States
Related Faculty: 
Luigi Marchionni, M.D., Ph.D.

Pathology & Laboratory Medicine 1300 York Avenue New York, NY 10065 Phone: (212) 746-6464
Surgical Pathology: (212) 746-2700