|Title||Plasma accumulation of metabolism of orally administered single dose L-5-hydroxytryptophan in man.|
|Publication Type||Journal Article|
|Year of Publication||1981|
|Authors||Magnussen I, Jensen TS, Rand JH, Van Woert MH|
|Journal||Acta Pharmacol Toxicol (Copenh)|
|Date Published||1981 Sep|
|Keywords||5-Hydroxytryptophan, Administration, Oral, Adolescent, Adult, Aromatic Amino Acid Decarboxylase Inhibitors, Carbidopa, Humans, Hydroxyindoleacetic Acid, Intestinal Absorption, Serotonin|
Single oral doses of L-5-hydroxytryptophan (5-HTP) were administered in combination with L-aromatic amino acid decarboxylase inhibitors. The time courses of plasma concentrations of 5-HTP, 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) and the concentrations of 5-HT in blood platelets were measured. Carbidopa enhanced the rise in plasma concentrations of 5-HTP 5-15 fold and counteracted the increase in plasma 5-HIAA levels induced by 5-HTP alone. A single dose of the decarboxylase inhibitor was equipotent to 14 days' pretreatment. Plasma or platelet concentrations of 5-HT failed to reflect the metabolism of 5-HTP. The ratio of 5-HTP to carbidopa influenced the systemic bioavailability of single dose administered 5-HTP indicating dose dependent absorption kinetics. Co-administration of L-dopa with 5-HTP and decarboxylase inhibitors had no effect on gastrointestinal absorption of 5-HTP in six parkinsonian patients.
|Alternate Journal||Acta Pharmacol Toxicol (Copenh)|
|Grant List||NS 12341 / NS / NINDS NIH HHS / United States |
RR 00071 / RR / NCRR NIH HHS / United States
Jacob H. Rand, M.D.