Title | Pediatric Myelodysplastic Syndromes. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Patel SS |
Journal | Clin Lab Med |
Volume | 41 |
Issue | 3 |
Pagination | 517-528 |
Date Published | 2021 09 |
ISSN | 1557-9832 |
Abstract | Pediatric myelodysplastic syndromes (MDS) comprise less than 5% of childhood malignancies. Approximately 30% to 45% of pediatric MDS cases are associated with an underlying genetic predisposition syndrome. A subset of patients present with MDS/acute myeloid leukemia (AML) following intensive chemotherapy for an unrelated malignancy. A definitive diagnosis of MDS can often only be rendered pending a comprehensive clinical and laboratory-based evaluation, which frequently includes ancillary testing in a reference laboratory. Clinical subtypes, the current diagnostic schema, and the results of more recently performed next-generation sequencing studies in pediatric MDS are discussed here. |
DOI | 10.1016/j.cll.2021.03.015 |
Alternate Journal | Clin Lab Med |
PubMed ID | 34304779 |
Related Faculty:
Sanjay Patel, M.D., MPH