| Title | p62 in Cancer: Signaling Adaptor Beyond Autophagy. |
| Publication Type | Journal Article |
| Year of Publication | 2016 |
| Authors | Moscat J, Karin M, Diaz-Meco MT |
| Journal | Cell |
| Volume | 167 |
| Issue | 3 |
| Pagination | 606-609 |
| Date Published | 2016 Oct 20 |
| ISSN | 1097-4172 |
| Keywords | Autophagy, Carcinogenesis, Epithelial Cells, Humans, Neoplasms, Sequestosome-1 Protein, Signal Transduction, Stress, Physiological, Tumor Microenvironment |
| Abstract | Adaptor proteins participate in selective autophagy, which is critical for cellular detoxification and stress relief. However, new evidence supports an autophagy-independent key role of the adaptor p62 (encoded by the gene Sqstm1) in signaling functions central to tumor initiation in the epithelium and suppression of tumor progression in the stroma. |
| DOI | 10.1016/j.cell.2016.09.030 |
| Alternate Journal | Cell |
| PubMed ID | 27768885 |
| PubMed Central ID | PMC5114003 |
| Grant List | R01 DK108743 / DK / NIDDK NIH HHS / United States R01 CA192642 / CA / NCI NIH HHS / United States P01 DK098108 / DK / NIDDK NIH HHS / United States P42 ES010337 / ES / NIEHS NIH HHS / United States R01 CA172025 / CA / NCI NIH HHS / United States R01 CA211794 / CA / NCI NIH HHS / United States P30 CA030199 / CA / NCI NIH HHS / United States R01 CA118165 / CA / NCI NIH HHS / United States R01 CA163798 / CA / NCI NIH HHS / United States |
Related Faculty:
Maria Diaz-Meco Conde, Ph.D.