Title | Osteoblast-Osteoclast Communication and Bone Homeostasis. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Kim J-M, Lin C, Stavre Z, Greenblatt MB, Shim J-H |
Journal | Cells |
Volume | 9 |
Issue | 9 |
Date Published | 2020 09 10 |
ISSN | 2073-4409 |
Keywords | Bone and Bones, Bone Remodeling, Cell Communication, Cell Differentiation, Homeostasis, Humans, Osteoblasts, Osteoclasts, Signal Transduction |
Abstract | Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell-to-cell contact or through secretory proteins. A direct interaction between osteoblasts and osteoclasts allows bidirectional transduction of activation signals through EFNB2-EPHB4, FASL-FAS or SEMA3A-NRP1, regulating differentiation and survival of osteoblasts or osteoclasts. Alternatively, osteoblasts produce a range of different secretory molecules, including M-CSF, RANKL/OPG, WNT5A, and WNT16, that promote or suppress osteoclast differentiation and development. Osteoclasts also influence osteoblast formation and differentiation through secretion of soluble factors, including S1P, SEMA4D, CTHRC1 and C3. Here we review the current knowledge regarding membrane bound- and soluble factors governing cross-talk between osteoblasts and osteoclasts. |
DOI | 10.3390/cells9092073 |
Alternate Journal | Cells |
PubMed ID | 32927921 |
PubMed Central ID | PMC7564526 |
Grant List | R01 AR068983 / AR / NIAMS NIH HHS / United States DP5 OD021351 / OD / NIH HHS / United States R01 AR075585 / AR / NIAMS NIH HHS / United States |
Related Faculty:
Matthew B. Greenblatt, M.D., Ph.D.