Oncogenes come of age.

TitleOncogenes come of age.
Publication TypeJournal Article
Year of Publication2005
AuthorsVarmus H, Pao W, Politi K, Podsypanina K, Du Y-CN
JournalCold Spring Harb Symp Quant Biol
Volume70
Pagination1-9
Date Published2005
ISSN0091-7451
KeywordsAdenocarcinoma, Animals, Drug Resistance, Neoplasm, Genes, erbB-1, Genotype, Humans, Lung Neoplasms, Mice, Mutation, Neoplasms, Neoplasms, Experimental, Oncogenes, Protein Kinase Inhibitors, Proto-Oncogenes
Abstract

Mutations of proto-oncogenes are common events in the pathogenesis of cancers, as shown in a wide range of studies during the 30 years since the discovery of these genes. The benefits of novel therapies that target the products of mutant alleles in human cancers, and the demonstrated dependence of cancers in mouse models on continued expression of initiating oncogenes, are especially promising signs that revolutionary improvements in cancer care are possible. Full realization of the promise of targeted therapies, however, will require better definitions of the genotypes of human cancers, new approaches to interrupt the biochemical consequences of oncogenic mutations, and a greater understanding of drug resistance and tumor progression. In this paper, we summarize recent efforts toward these goals in our laboratory and others.

DOI10.1101/sqb.2005.70.039
Alternate JournalCold Spring Harb Symp Quant Biol
PubMed ID16869733
PubMed Central IDPMC1791364
Grant ListP01 CA094060 / CA / NCI NIH HHS / United States
P01 CA94060-02 / CA / NCI NIH HHS / United States
Related Lab: 
Related Faculty: 
Yi-Chieh (Nancy) Du, Ph.D.

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