| Title | Nuclear signaling by interleukin-6. |
| Publication Type | Journal Article |
| Year of Publication | 1993 |
| Authors | Chen-Kiang S, Hsu W, Natkunam Y, Zhang X |
| Journal | Curr Opin Immunol |
| Volume | 5 |
| Issue | 1 |
| Pagination | 124-8 |
| Date Published | 1993 Feb |
| ISSN | 0952-7915 |
| Keywords | Animals, DNA-Binding Proteins, Gene Expression Regulation, Genes, Immunoglobulin, Humans, Interleukin-6, Leucine Zippers, Multigene Family, Octamer Transcription Factor-2, Proto-Oncogene Proteins c-jun, Retinoblastoma Protein, Signal Transduction, Transcription Factors, Virus Diseases |
| Abstract | The molecular analysis of the regulation of nuclear proteins induced by interleukin-6 has provided new insights into this largely unknown signal transduction pathway. Transcription factors of the CCAAT/enhancer-binding protein and AP-1 families, as well as the octamer-binding proteins and the tumor suppressor gene product pRB, are regulated by interleukin-6 in a cell type specific manner, suggesting that they may play a role in the nuclear signaling by interleukin-6. |
| DOI | 10.1016/0952-7915(93)90091-6 |
| Alternate Journal | Curr Opin Immunol |
| PubMed ID | 8452668 |
Related Faculty:
Selina Chen-Kiang, Ph.D.