Nuclear signaling by interleukin-6.

TitleNuclear signaling by interleukin-6.
Publication TypeJournal Article
Year of Publication1993
AuthorsChen-Kiang S, Hsu W, Natkunam Y, Zhang X
JournalCurr Opin Immunol
Date Published1993 Feb
KeywordsAnimals, DNA-Binding Proteins, Gene Expression Regulation, Genes, Immunoglobulin, Humans, Interleukin-6, Leucine Zippers, Multigene Family, Octamer Transcription Factor-2, Proto-Oncogene Proteins c-jun, Retinoblastoma Protein, Signal Transduction, Transcription Factors, Virus Diseases

The molecular analysis of the regulation of nuclear proteins induced by interleukin-6 has provided new insights into this largely unknown signal transduction pathway. Transcription factors of the CCAAT/enhancer-binding protein and AP-1 families, as well as the octamer-binding proteins and the tumor suppressor gene product pRB, are regulated by interleukin-6 in a cell type specific manner, suggesting that they may play a role in the nuclear signaling by interleukin-6.

Alternate JournalCurr Opin Immunol
PubMed ID8452668
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