| Title | NF-kappaB signaling modulation by EBV and KSHV. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | de Oliveira DElgui, Ballon G, Cesarman E |
| Journal | Trends Microbiol |
| Volume | 18 |
| Issue | 6 |
| Pagination | 248-57 |
| Date Published | 2010 Jun |
| ISSN | 1878-4380 |
| Keywords | Animals, Cell Transformation, Neoplastic, Epstein-Barr Virus Infections, Gene Expression Regulation, Viral, Herpesviridae Infections, Herpesvirus 4, Human, Herpesvirus 8, Human, Humans, Intercellular Signaling Peptides and Proteins, Mice, Neoplasms, NF-kappa B, Signal Transduction |
| Abstract | The nuclear factor (NF)-kappaB signaling pathway is pivotal for immune system function. Not surprisingly, pathogenic microorganisms have developed strategies to subvert it. Two examples are Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV), oncogenic gammaherpesviruses that establish a lifelong latent infection in their human hosts. The modulation of NF-kappaB signaling by EBV and KSHV is not only important for viral infection, but also contributes to the development of malignant neoplasia. This review explores the current knowledge of NF-kappaB modulation by EBV and KSHV, focusing on connections between viral biology and human carcinogenesis. |
| DOI | 10.1016/j.tim.2010.04.001 |
| Alternate Journal | Trends Microbiol |
| PubMed ID | 20452220 |
Related Faculty:
Ethel Cesarman, M.D., Ph.D.