Multiple malignant transformations of an ovarian mature cystic teratoma.

TitleMultiple malignant transformations of an ovarian mature cystic teratoma.
Publication TypeJournal Article
Year of Publication2020
AuthorsCagino K, Levitan D, Schatz-Siemers N, Zarnegar R, Chapman-Davis E, Holcomb K, Frey M
Date Published2020

Background: Malignant transformation of mature cystic teratomas (MCTs) is a rare phenomenon. The most common histology of a malignant transformation is squamous cell carcinoma, and there are limited reports of multiple malignancies arising in a single MCT. Further data are necessary to guide management of these atypical cases.

Case: We present the case of a 48-year-old with MCT containing a malignant papillary thyroid carcinoma (PTC) arising in the context of struma ovarii and a carcinoid tumour.

Conclusion: Malignant transformations of MCTs are exceedingly rare with no guidelines on management. We use this case to demonstrate an approach for the workup and management of malignantly transformed MCTs.

Alternate JournalEcancermedicalscience
PubMed ID32256692
PubMed Central IDPMC7105337
Related Faculty: 
Nina Schatz-Siemers, D.O.

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