Of mice and women: a comparative tissue biology perspective of breast stem cells and differentiation.

TitleOf mice and women: a comparative tissue biology perspective of breast stem cells and differentiation.
Publication TypeJournal Article
Year of Publication2015
AuthorsDontu G, Ince TA
JournalJ Mammary Gland Biol Neoplasia
Volume20
Issue1-2
Pagination51-62
Date Published2015 Jun
ISSN1573-7039
KeywordsAnimals, Carcinoma, Cell Differentiation, Cell Lineage, Female, Flow Cytometry, Histology, Comparative, Humans, Immunohistochemistry, Keratins, Mammary Glands, Animal, Mammary Glands, Human, Mice, Stem Cells
Abstract

Tissue based research requires a background in human and veterinary pathology, developmental biology, anatomy, as well as molecular and cellular biology. This type of comparative tissue biology (CTB) expertise is necessary to tackle some of the conceptual challenges in human breast stem cell research. It is our opinion that the scarcity of CTB expertise contributed to some erroneous interpretations in tissue based research, some of which are reviewed here in the context of breast stem cells. In this article we examine the dissimilarities between mouse and human mammary tissue and suggest how these may impact stem cell studies. In addition, we consider the differences between breast ducts vs. lobules and clarify how these affect the interpretation of results in stem cell research. Lastly, we introduce a new elaboration of normal epithelial cell types in human breast and discuss how this provides a clinically useful basis for breast cancer classification.

DOI10.1007/s10911-015-9341-4
Alternate JournalJ Mammary Gland Biol Neoplasia
PubMed ID26286174
PubMed Central IDPMC4595531

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