Mechanism of BLyS action in B cell immunity.

TitleMechanism of BLyS action in B cell immunity.
Publication TypeJournal Article
Year of Publication2002
AuthorsDo RKinh Gian, Chen-Kiang S
JournalCytokine Growth Factor Rev
Date Published2002 Feb
KeywordsAnimals, B-Cell Activating Factor, B-Cell Activation Factor Receptor, B-Lymphocytes, Humans, Ligands, Membrane Proteins, Mice, Mice, Transgenic, Models, Biological, Protein Binding, Receptors, Tumor Necrosis Factor, Signal Transduction, Tumor Necrosis Factor-alpha

The B lymphocyte stimulator (BLyS), also known as BAFF, THANK, TALL-1 and zTNF4, is the most recent addition to the tumor necrosis factor family (TNF) ligands and has a unique role in B cell immunity. Its requirement for the humoral immune response is evident in mice lacking BlyS, which exhibit profound deficiencies in peripheral B cell development and maturation. It regulates the antibody response, as shown in mice overexpressing BLyS, which develop autoimmune manifestations resulting from peripheral B cell expansion and differentiation. Attenuation of apoptosis appears to underlie BLyS action in B cells. However, elucidation of the mechanism of BLyS has proven to be more challenging, because BLyS binds three different TNF receptors (TACI/BCMA/BAFF-R) and shares overlapping functions with a related TNF ligand, APRIL. The unique role of BLyS in B cell development and differentiation and the pathogenesis of autoimmune diseases, systemic lupus erythematosus (SLE) in particular, makes the study of BLyS and its downstream targets attractive in the development of novel therapies.

Alternate JournalCytokine Growth Factor Rev
PubMed ID11750877
Grant ListAR44580 / AR / NIAMS NIH HHS / United States
CA80204 / CA / NCI NIH HHS / United States
GM07739 / GM / NIGMS NIH HHS / United States
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