Lysophospholipids--receptor revelations.

TitleLysophospholipids--receptor revelations.
Publication TypeJournal Article
Year of Publication2001
AuthorsHla T, Lee MJ, Ancellin N, Paik JH, Kluk MJ
JournalScience
Volume294
Issue5548
Pagination1875-8
Date Published2001 Nov 30
ISSN0036-8075
KeywordsAnimals, Heterotrimeric GTP-Binding Proteins, Humans, Lysophospholipids, Phylogeny, Receptors, Cell Surface, Receptors, G-Protein-Coupled, Receptors, Lysophosphatidic Acid, Receptors, Lysophospholipid, Signal Transduction, Sphingosine
Abstract

Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein-coupled receptors for LPs in higher eukaryotes, and their involvement in regulating diverse processes such as angiogenesis, cardiac development, neuronal survival, and immunity, has stimulated growing interest in these lipid mediators. LP receptor biology has generated insights into fundamental cellular mechanisms and may provide therapeutic targets for drug development.

DOI10.1126/science.1065323
Alternate JournalScience
PubMed ID11729304
Grant ListDK45659 / DK / NIDDK NIH HHS / United States
HL67330 / HL / NHLBI NIH HHS / United States
Related Faculty: 
Ji-Hye Paik, Ph.D. Michael Kluk, M.D., Ph.D.

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