Linear IgA bullous dermatosis in the setting of angioimmunoblastic T-cell lymphoma.

TitleLinear IgA bullous dermatosis in the setting of angioimmunoblastic T-cell lymphoma.
Publication TypeJournal Article
Year of Publication2023
AuthorsAndriano TM, Tannenbaum R, Xu H, Magro CM
JournalJ Cutan Pathol
Volume50
Issue1
Pagination43-46
Date Published2023 Jan
ISSN1600-0560
KeywordsAged, 80 and over, Humans, Linear IgA Bullous Dermatosis, Lymphoma, T-Cell, Male, Plasma Cells, Skin Diseases, Vesiculobullous
Abstract

We report an 80-year-old male developing linear IgA bullous dermatosis (LAD) in the setting of angioimmunoblastic T-cell lymphoma (AITL). This phenomenon is rare, as only three cases have been described in the literature. The pathophysiologic process can be attributed to dysregulation in somatic hypermutation and the expression of chemokine receptor 5 in AITL, contributing to increased IgA. Immunoglobulin production resulting from clonal plasma cell expansion may be because of the B-cell promotional effect by neoplastic follicular helper T-cells. Beyond providing a pathophysiologic platform for AITL-associated LAD, we also briefly summarized prior cases. This report demonstrates the importance of considering LAD in the differential diagnosis for patients with a bullous eruption in the setting of AITL.

DOI10.1111/cup.14309
Alternate JournalJ Cutan Pathol
PubMed ID35942597
Related Faculty: 
Cynthia M. Magro, M.D.

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