Title | Linear IgA bullous dermatosis in the setting of angioimmunoblastic T-cell lymphoma. |
Publication Type | Journal Article |
Year of Publication | 2023 |
Authors | Andriano TM, Tannenbaum R, Xu H, Magro CM |
Journal | J Cutan Pathol |
Volume | 50 |
Issue | 1 |
Pagination | 43-46 |
Date Published | 2023 Jan |
ISSN | 1600-0560 |
Keywords | Aged, 80 and over, Humans, Linear IgA Bullous Dermatosis, Lymphoma, T-Cell, Male, Plasma Cells, Skin Diseases, Vesiculobullous |
Abstract | We report an 80-year-old male developing linear IgA bullous dermatosis (LAD) in the setting of angioimmunoblastic T-cell lymphoma (AITL). This phenomenon is rare, as only three cases have been described in the literature. The pathophysiologic process can be attributed to dysregulation in somatic hypermutation and the expression of chemokine receptor 5 in AITL, contributing to increased IgA. Immunoglobulin production resulting from clonal plasma cell expansion may be because of the B-cell promotional effect by neoplastic follicular helper T-cells. Beyond providing a pathophysiologic platform for AITL-associated LAD, we also briefly summarized prior cases. This report demonstrates the importance of considering LAD in the differential diagnosis for patients with a bullous eruption in the setting of AITL. |
DOI | 10.1111/cup.14309 |
Alternate Journal | J Cutan Pathol |
PubMed ID | 35942597 |
Related Faculty:
Cynthia M. Magro, M.D.