Title | Ketoprofen S(+) enantiomer inhibits prostaglandin production and cell growth in 3T6 fibroblast cultures. |
Publication Type | Journal Article |
Year of Publication | 1999 |
Authors | Sanchez T, Moreno JJ |
Journal | Eur J Pharmacol |
Volume | 370 |
Issue | 1 |
Pagination | 63-7 |
Date Published | 1999 Apr 01 |
ISSN | 0014-2999 |
Keywords | Animals, Anti-Inflammatory Agents, Non-Steroidal, Cell Division, Cell Survival, Cells, Cultured, Dinoprostone, DNA, Fibroblasts, Ketoprofen, Mice, Stereoisomerism, Thymidine |
Abstract | The ketoprofen S(+) enantiomer inhibits with great stereoselectivity both prostaglandin H synthase isoenzymes. Thus, the biological effects of ketoprofen on inflammation are due almost entirely to the S(+) isomer. Here, we report that the S(+) enantiomer, at doses that inhibit prostaglandin synthesis, is effective in reducing DNA synthesis and 3T6 fibroblast growth. Our data suggest that prostaglandins are involved in the control of 3T6 fibroblast growth and that the effect of the ketoprofen S(+) enantiomer on 3T6 proliferation is correlated with its effects on prostaglandin H synthase and prostaglandin production. |
DOI | 10.1016/s0014-2999(99)00108-9 |
Alternate Journal | Eur J Pharmacol |
PubMed ID | 10323281 |
Related Faculty:
Teresa Sanchez, Ph.D.