| Title | Intracranial nasal natural killer/T-cell lymphoma: immunopathologically-confirmed case and review of literature. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Luther N, Greenfield JP, Chadburn A, Schwartz TH |
| Journal | J Neurooncol |
| Volume | 75 |
| Issue | 2 |
| Pagination | 185-8 |
| Date Published | 2005 Nov |
| ISSN | 0167-594X |
| Keywords | Adult, Anti-Bacterial Agents, CD3 Complex, CD4 Antigens, CD56 Antigen, Craniotomy, Fatal Outcome, Follow-Up Studies, Humans, Immunophenotyping, Killer Cells, Natural, Lymphoma, T-Cell, Magnetic Resonance Imaging, Male, Nose Neoplasms, Pseudomonas aeruginosa, Staphylococcus aureus, Time Factors |
| Abstract | Advances in immunophenotypic profiling now permit characterization of natural killer/T-cell (NK/T-cell) lymphoma as distinct from other extranodal T- and B-cell Non-Hodgkin's lymphomas. NK/T-cell lymphoma presents most commonly in the nasal cavity. Disease progression to the central nervous system (CNS) is a rare phenomenon. We present here, to our knowledge, the first immunophenotypically-confirmed case of direct extension of nasal NK/T-cell lymphoma to the brain. In addition, we review the literature with respect to NK/T-cell lymphoma metastasis to the CNS. The overall prevalence of NK/T-cell lymphoma CNS metastasis is less than 3%. Although rare, CNS invasion portends a poor prognosis, emphasizing the importance of early and accurate immunophenotype profiling and the need for novel, aggressive therapy. |
| DOI | 10.1007/s11060-005-1862-z |
| Alternate Journal | J Neurooncol |
| PubMed ID | 16283442 |
Related Faculty:
Amy Chadburn, M.D.