Interpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer.

TitleInterpathologist concordance in the histological diagnosis of focal prostatic atrophy lesions, acute and chronic prostatitis, PIN, and prostate cancer.
Publication TypeJournal Article
Year of Publication2017
AuthorsGiunchi F, Jordahl K, Bollito E, Colecchia M, Patriarca C, D'Errico A, Vasuri F, Malvi D, Fornari A, Bonetti LReggiani, Corti B, Papotti M, DeGiuli P, Loda M, Montironi R, Fiorentino M, Rider JR
JournalVirchows Arch
Volume470
Issue6
Pagination711-715
Date Published2017 Jun
ISSN1432-2307
KeywordsAtrophy, Chronic Disease, Humans, Male, Observer Variation, Prostate, Prostatic Intraepithelial Neoplasia, Prostatic Neoplasms, Prostatitis
Abstract

Epidemiological and biological evidence indicates a causal relationship between the presence of proliferative atrophic lesions and the development of prostatic intraepithelial neoplasia (PIN) and prostate cancer. The presence of inflammatory and atrophic lesions of the prostate is widely underestimated and they are not generally mentioned in pathology reports. We performed a histopathological concordance study among eight genitourinary specialists and seven generalist pathologists, using 116 histological slides of prostate lesions, including proliferative atrophic lesions, PIN, and cancer. The overall agreement between all possible pairs of reviewers was 80% for prostate cancer, 67% for PIN, and 49% for proliferative atrophic lesions. When using as gold standard the assessment of a single genitourinary pathologist, the mean agreement percentage increased to 97% for prostate cancer, 92% for PIN, and 72% for proliferative atrophic lesions.

DOI10.1007/s00428-017-2123-1
Alternate JournalVirchows Arch
PubMed ID28405833
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