| Title | Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile. |
| Publication Type | Journal Article |
| Year of Publication | 2000 |
| Authors | Churchill M, Chadburn A, Bilinski RT, Bertagnolli MM |
| Journal | J Surg Res |
| Volume | 89 |
| Issue | 2 |
| Pagination | 169-75 |
| Date Published | 2000 Apr |
| ISSN | 0022-4804 |
| Keywords | Adenomatous Polyposis Coli Protein, Animals, Antineoplastic Agents, B-Lymphocytes, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Curcumin, Cytoskeletal Proteins, Germ-Line Mutation, Immune System, Immunohistochemistry, Intestinal Mucosa, Intestinal Neoplasms, Intestines, Lymphocyte Count, Mice, Mice, Inbred C57BL, Mice, Mutant Strains |
| Abstract | BACKGROUND: The C57BL/6J-Min/+ (Min/+) mouse bears a germline mutation in Apc and is therefore a model for familial adenomatous polyposis and sporadic colorectal cancer. Min/+ intestinal mucosa exhibits a marked tendency for spontaneous adenoma formation. Curcumin is a phenolic antioxidant known for its antitumor and immune modulatory functions in vitro. Curcumin prevents adenoma formation in Min/+ mice, through a mechanism that may be related to its immunomodulatory properties. MATERIALS AND METHODS: To study the relationship between intestinal immunity and curcumin-induced antitumor response, we used immunohistochemistry to characterize the effect of curcumin treatment on resident intestinal immune effector cells in Min/+ mice. RESULTS/CONCLUSION: These results show that mucosal CD4(+) T cells and B cells increase in animals treated with curcumin, suggesting that curcumin modulates lymphocyte-mediated immune functions. |
| DOI | 10.1006/jsre.2000.5826 |
| Alternate Journal | J Surg Res |
| PubMed ID | 10729246 |
| Grant List | 1R29CA74162-01 / CA / NCI NIH HHS / United States |
Related Faculty:
Amy Chadburn, M.D.