Inhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile.

TitleInhibition of intestinal tumors by curcumin is associated with changes in the intestinal immune cell profile.
Publication TypeJournal Article
Year of Publication2000
AuthorsChurchill M, Chadburn A, Bilinski RT, Bertagnolli MM
JournalJ Surg Res
Date Published2000 Apr
KeywordsAdenomatous Polyposis Coli Protein, Animals, Antineoplastic Agents, B-Lymphocytes, CD4 Lymphocyte Count, CD4-Positive T-Lymphocytes, Curcumin, Cytoskeletal Proteins, Germ-Line Mutation, Immune System, Immunohistochemistry, Intestinal Mucosa, Intestinal Neoplasms, Intestines, Lymphocyte Count, Mice, Mice, Inbred C57BL, Mice, Mutant Strains

BACKGROUND: The C57BL/6J-Min/+ (Min/+) mouse bears a germline mutation in Apc and is therefore a model for familial adenomatous polyposis and sporadic colorectal cancer. Min/+ intestinal mucosa exhibits a marked tendency for spontaneous adenoma formation. Curcumin is a phenolic antioxidant known for its antitumor and immune modulatory functions in vitro. Curcumin prevents adenoma formation in Min/+ mice, through a mechanism that may be related to its immunomodulatory properties.

MATERIALS AND METHODS: To study the relationship between intestinal immunity and curcumin-induced antitumor response, we used immunohistochemistry to characterize the effect of curcumin treatment on resident intestinal immune effector cells in Min/+ mice.

RESULTS/CONCLUSION: These results show that mucosal CD4(+) T cells and B cells increase in animals treated with curcumin, suggesting that curcumin modulates lymphocyte-mediated immune functions.

Alternate JournalJ Surg Res
PubMed ID10729246
Grant List1R29CA74162-01 / CA / NCI NIH HHS / United States
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Amy Chadburn, M.D.

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